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Individualized intervention strategies in the treatment of childhood and adolescent obesity based on precision medicine LI Ping, YANG Fan, LIU Hanmin Chinese Pediatrics of Integrated Traditional and Western Medicine    2025, 17 (1): 1-7.   DOI: 10.20274/j.cnki.issn.1674-3865.2025.01.001 Abstract （3654）      PDF（pc） （1165KB）（4874）       Knowledge map    Save Childhood and adolescent obesity has become a global challenge in public health.Its high weight regain rate and risks of metabolic complications highlight the limitations of traditional intervention strategies.This review systematically explores individualized intervention strategies for obesity in children and adolescents in the context of precision medicine,breaking the traditional "one-size-fits-all" model.It integrates multi-omics technologies with intelligent management methods,proposing a multidimensional framework for precise intervention.First,a precise diagnosis and evaluation system is constructed based on multi-modal data,including genomics,radiomics,and gut microbiomics,to identify genetic susceptibility,metabolic phenotypes and microbiome characteristics,laying the foundation for stratified interventions.Secondly,individualized intervention plans are developed based on genetic risk scores,epigenetic regulatory mechanisms,and gut microbiome-targeted therapies:gene-guided strategies aim to optimize dietary structure through multi-gene risk assessments; epigenetic interventions aim to regulate DNA methylation and histone modification by taking advantage of nutrients (such as methyl donors and short-chain fatty acids),reversing metabolic dysregulation; microbiome remodeling aims to improve energy metabolism balance through probiotics and synbiotics.Furthermore,artificial intelligence and wearable devices are employed for dynamic monitoring in multiple scenarios.By collaborating with multidisciplinary teams in nutrition,sports medicine,and psychology,a smart management model of "hospital-family-community" network is established.While precision medicine offers groundbreaking directions for childhood obesity treatment,challenges such as biomarker validation,data integration,and long-term efficacy evaluation remain to be addressed.This review provides theoretical foundations and practical pathways for the improvement in the effectiveness and sustainability of interventions,emphasizing the need to integrate interdisciplinary innovative technologies in the future in order to promote the transformation of childhood obesity management toward precision and intelligence. Related Articles | Metrics

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Traditional Chinese medicine constitution analysis of children with attention deficit hyperactivity disorder (syndrome of heart and liver fire hyperactivity) ZHOU Min, WANG Minhua, LI Yaqun Chinese Pediatrics of Integrated Traditional and Western Medicine    2025, 17 (1): 54-58.   DOI: 10.20274/j.cnki.issn.1674-3865.2025.01.011 Abstract （3149）      PDF（pc） （1113KB）（2084）       Knowledge map    Save Objective To explore the distribution of traditional Chinese medicine(TCM) constitution in children with attention deficit hyperactivity disorder(ADHD) (syndrome of heart and liver fire hyperactivity),and its relationship with symptoms and social function of the children.Methods A total of 70 children aged 7 to 14 years with ADHD (syndrome of heart and liver fire hyperactivity) were included in the study,who were treated in Yixing Traditional Chinese Medicine Hospital from January 2023 to May 2024.The TCM syndrome scoring,SNAP-Ⅳ and CGAS were used to evaluate the severity of the symptoms and the impact on social function of the children,and the TCM constitution distribution was divided according to the TCM constitution scale.Results TCM syndrome score was (18.54 ± 2.84) in ADHD children (syndrome of heart and liver fire hyperactivity).The average SNAP-Ⅳ score of the boys was (41.02±8.56),the average SNAP-Ⅳ score of the girls was (41.19±8.46),the average CGAS score of the boys was (63.12±6.83),and the average CGAS score of the girls was (63.75±6.65),which significantly affected the children′s social function and normal life activities; the severity of the disease was not related to gender(P>0.05).Unbalanced constitution was the main type of TCM constitution,totaling 42 cases (60%),and 28 cases (40%) were with balanced constitution.Among the children with unbalanced constitutions,the number of children with qi-stagnation constitution,yin-deficiency constitution and qi-deficiency constitution was the highest (≥10%); the children with yin-deficiency constitution had the longest course of disease ［(4.25±0.41) years］,and the children with balanced constitution had the shortest course of disease ［(1.74±0.33) years］.Conclusion The TCM syndrome score of the 70 children with ADHD(syndrome of heart and liver fire hyperactivity) in Yixing area included in this study is high,which has a significant impact on the social function of the children,but there is no gender difference.Unbalanced constitution is the main type in the distribution of constitution,and the disease course of ADHD (syndrome of heart and liver fire hyperactivity) is different in children with different constitutions. Related Articles | Metrics

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Research progress in causes of premature puberty in traditional Chinese and western medicine LIU Qiannan, WANG Yanchao, MIAO Yizhuo, LI Lan Chinese Pediatrics of Integrated Traditional and Western Medicine    2025, 17 (1): 13-16.   DOI: 10.20274/j.cnki.issn.1674-3865.2025.01.003 Abstract （3140）      PDF（pc） （1085KB）（662）       Knowledge map    Save Since the 1970s,it has been believed in traditional Chinese medicine (TCM) that the pathogenesis of precocious puberty is primarily associated with yin-deficiency and fire-excess,and the treatments that nourish yin and purge fire are advocated.Therefore,an integrated treatment strategy combining TCM and western medicine has gradually been formulated.Modern medical research indicates that precocious puberty results from the interplay of genetic and environmental factors,involving heredity,diet,chemical substance interference,and psychological factors.TCM emphasizes the combined influence of internal and external factors,such as dietary irregularities and emotional disturbances,and focuses on therapeutic methods like nourishing yin,purging fire,soothing the liver,and relieving stagnation.The integrated approach of TCM and western medicine offers a more comprehensive treatment plan for precocious puberty.The TCM theory of "preventive treatment of disease" underscores the importance of prevention,reducing risk factors and performing proactive treatment to avoid long-term complications. Related Articles | Metrics

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Experience in the diagnosis and treatment of children's diseases from "accumulated internal heat" ZHANG Yu, XIAO Yang, ZHOU Mengxiao, SUN Liping Chinese Pediatrics of Integrated Traditional and Western Medicine    2025, 17 (1): 59-63.   DOI: 10.20274/j.cnki.issn.1674-3865.2025.01.012 Abstract （2941）      PDF（pc） （1073KB）（6642）       Knowledge map    Save The function of the spleen in children is often insufficient, and improper feeding, or disease damage may cause the fact that food can't be digested, which is food accumulation。Although it is a disease of the spleen, Professor Sun Liping believes that long time of food accumulation can form internal heat syndrome, thereby inducing a variety of pediatric diseases. Attention should be paid to the physical changes caused by congenital abnormality and acquired dystrophy. Based on the physiological and pathological characteristics of children, Yin and Yang theory, five-element theory and constitution theory, and through combination with more than 30 years of clinical experience of Professor Sun Liping, this paper explores the etiology and pathogenesis of children's diseases caused by "food", the disease outcome transformed by "heat", the diagnosis experience from "observation", and the treatment method by "elimination". A new line of thinking of "same treatment for different diseases" is provided for the diagnosis and treatment of abdominal pain, cough, asthma and tic disorders caused by food accumulation. Related Articles | Metrics

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Research on the clinical application of Zhimu-Huangbai in precocious puberty CHEN Na, LI Lianke, LU Yihong, YANG Yang, TAO Qiong, CHEN Zhu Chinese Pediatrics of Integrated Traditional and Western Medicine    2025, 17 (1): 8-12.   DOI: 10.20274/j.cnki.issn.1674-3865.2025.01.002 Abstract （2938）      PDF（pc） （1083KB）（643）       Knowledge map    Save Zhimu-Huangbai is a commonly used medicine pair in clinical practice,and the compatibility of the two drugs has the effects of nourishing yin and clearing heat,purging fire and detoxifying.Modern studies have found that Zhimu-Huangbai has anti-inflammatory,antioxidant,hypoglycemic,and lipidemic regulation effects because of its main active ingredients such as quercetin,kaempferol,barmatine,stigmasterol,mangiferin,berberine,etc.It is widely used in clinical practice,mainly for the treatment of precocious puberty,diabetes,diabetic nephropathy and other diseases in children.From the perspectives of chemical composition,pharmacological effects and clinical application,this paper expounds the application research of Zhimu-Huangbai in precocious puberty in recent years,in order to provide a theoretical basis for the scientific application of the drug in precocious puberty and for the research and development of new drugs. Related Articles | Metrics

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Treatment for pediatric pulmonary diseases based on the theory of "lungs governing skin and hair" and the method of "analogy and classification"  WEI Jiaxuan, YANG Jianhui, FENG Zhongfa, LI Rong, ZHAO Shun, LIU Qiaoya Chinese Pediatrics of Integrated Traditional and Western Medicine    2025, 17 (1): 75-78.   DOI: 10.20274/j.cnki.issn.1674-3865.2025.01.016 Abstract （2887）      PDF（pc） （1062KB）（3305）       Knowledge map    Save This paper explores the application value of Traditional Chinese Medicine (TCM) theory of "lungs governing skin and hair" and the thinking method of "analogy and classification" in the treatment of pediatric pulmonary diseases.Both "lungs governing skin and hair" and "analogy and classification" are traditional TCM theoretical approaches guiding clinical differential diagnosis and treatment.By discussing the correlation between the lungs and the skin and hair,and then employing the method of analogy and classification,this paper explores the feasibility and efficacy of treating pulmonary diseases by the "skin"-cortex (the character of skin and cortex is the same in Chinese).Starting from the physiological characteristics of children,such as "lung deficiency" and loose cutaneous layers,the paper argues that "cortex-related" herbal medicines (e.g.,Baixian Pi,Hou Po,and Chan Tui) can improve the pathological features of being easily invaded by external pathogens in children.Through case studies,this paper demonstrates a formula containing cortex-related herbs in the treatment of cough (wind-phlegm obstructing the lung) in a 4-year-old child,which is very effective.The results confirm the clinical feasibility of this approach.By integrating traditional TCM theories with modern scientific validation,this paper provides new insights into the diagnosis and treatment of pediatric pulmonary diseases,highlighting the unique advantages of TCM in the field of pediatrics. Related Articles | Metrics

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Current research status of the influence of dietary patterns on precocious puberty in children LIU Ziqi, ZHANG Guiju Chinese Pediatrics of Integrated Traditional and Western Medicine    2025, 17 (1): 17-22.   DOI: 10.20274/j.cnki.issn.1674-3865.2025.01.004 Abstract （2833）      PDF（pc） （1129KB）（1334）       Knowledge map    Save When children enter puberty,they will experience prominent changes mainly in the morphology of their reproductive organs,and development of function and secondary sexual characteristics.The main manifestation of precocious puberty is the earlier development of secondary sexual characteristics and the premature maturation of sexual organs,which is an endocrine disease characterized by abnormal growth and development of children.With the development of economy and society,the advancement of the onset age of precocious puberty and the increase in incidence rate have triggered increasing social attention.Multiple factors can have an impact on precocious puberty,and modern researches have confirmed a correlation between the daily diet of children before puberty and precocious puberty.This article reviews domestic and foreign researches in common dietary patterns and various dietary nutrients related to adolescent sexual development in children,represented by high calorie diet patterns,Mediterranean diet patterns,and vegetarian diet patterns,and it summarizes the influence of different dietary patterns on precocious puberty in children.The article respectively summarizes the potential regulatory mechanisms of high protein diet,high-fat diet and high sugar diet in high calorie diet patterns,as well as the main dietary components (vegetables,fruits,olive oil,grains,nuts,beans,and dairy products) in Mediterranean diet patterns and vegetarian diet patterns in sexual development.The aim is to provide theoretical basis for the prevention and treatment of precocious puberty in children from the perspective of dietary intervention,and to provide new ideas for future researches on the relationship between dietary nutrition structure and sexual development. Related Articles | Metrics

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Analysis of risk factors for hyperuricemia in children of different ages FANG Yanying, GAN Jiahui, XU Yuyin, XU Ziying, SITU Meiling, YU Shujuan Chinese Pediatrics of Integrated Traditional and Western Medicine    2025, 17 (1): 45-49.   DOI: 10.20274/j.cnki.issn.1674-3865.2025.01.009 Abstract （2825）      PDF（pc） （1099KB）（467）       Knowledge map    Save Objective To measure serum uric acid(SUA) levels in children of different ages(0 to 14 years),investigate the incidence of high level of uric acid in those regions,and analyze its association with gender,age,body size-body mass index(BMI),and living habits［including consumption of seafood,consumption of long-boiled soup/stew,consumption of vegetables,consumption of beverages,consumption of sweets,daily water intake(mL) and daily exercise (min)］.Methods Totally 1 209 children visiting Kaiping City Centre Hospital and Kaiping Maternal and Child Health Hospital from January 2022 to September 2023 were enrolled in the study.Height/length,weight and SUA of the children were measured,and the children were grouped according to age and gender in order to investigate the SUA levels of children in different age groups and genders.In addition,the children were grouped according to the SUA level to investigate the current situation of uric acid and the incidence of hyperuricaemia in the region.In the meantime,the relationship between hyperuricaemia(HUA) in the children and their gender,age,body size-BMI and living habits were also investigated.Results The distribution of SUA levels showed no statistically significant difference between different genders(P>0.05). In children of different ages and body types, SUA levels exhibited a trend of gradual increase with age and body type growth. The overall detection rate of hyperuricemia was 20.18%(244/1 209), and the comparison of the detection rates of hyperuricemia between different genders showed no statistically significant difference(P>0.05). However, the comparison of hyperuricemia detection rates among different ages and body types showed statistically significant differences(P<0.01). Logistic regression analysis revealed that seafood consumption, beverage intake, and a preference for sweet foods were risk factors for hyperuricemia, while increased vegetable intake, fluid consumption, and appropriate exercise were protective factors for uric acid levels. Conclusion The level of SUA in children in Kaiping City increases with age and changes in body type, with no specific relation to gender; high-purine and high-sugar foods are risk factors for hyperuricemia. Related Articles | Metrics

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Diagnosis and treatment guideline for functional dyspepsia in children with the integrated traditional Chinese and western medicine WANG Xuefeng, WU Jie, GONG Sitang, XIONG Lei, JIANG Mizu, WANG Baoxi, XU Hua, PENG Yu Chinese Pediatrics of Integrated Traditional and Western Medicine    2024, 16 (6): 461-468.   DOI: 10.3969/j.issn.1674-3865.2024.06.001 Abstract （2813）      PDF（pc） （1049KB）（1400）       Knowledge map    Save Functional dyspepsia,as one of the most common functional diseases of upper digestive tract,seriously affects the quality of life and growth and development of children in China.Due to the changing definition and symptom spectrum of functional dyspepsia in children,its diagnosis and treatment are controversial.In order to standardize the diagnosis and treatment of children with functional dyspepsia with integrated traditional Chinese and western medicine,and effectively solve the clinical problems in the diagnosis and treatment of children with functional dyspepsia,this guideline is formulated to guide the standardized diagnosis and treatment of children with functional dyspepsia with integrated traditional Chinese and western medicine. Related Articles | Metrics

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Application of San Yin Zhi Yi in the treatment of children with cough variant asthma LIANG Chaoqi, LONG Hongyan Chinese Pediatrics of Integrated Traditional and Western Medicine    2025, 17 (1): 79-83.   DOI: 10.20274/j.cnki.issn.1674-3865.2025.01.017 Abstract （2781）      PDF（pc） （1080KB）（2689）       Knowledge map    Save Pediatric cough variant asthma (CVA) is a common chronic respiratory disease primarily characterized by chronic cough. The exact etiology of CVA is not yet fully understood, but it is widely believed that the progression of the disease is influenced by various pathological factors, and is closely related to the patient's individual constitution, seasonal changes, and regional environmental characteristics. Traditional Chinese medicine (TCM) categorizes CVA under "wind cough", "wheezing cough", and "spasmodic cough", and pediatric CVA is managed according to the principle of "San Yin Zhi Yi"(three-cause adaptation), which involves personalized adjustments of the treatment plan based on the patient's constitution, seasonal changes and regional environment, reflecting the holistic treatment concept and syndrome-differentiation treatment of TCM. Therefore, this article discusses the etiology and pathogenesis of pediatric CVA from the perspectives of both TCM and modern medicine, based on the TCM principle of "San Yin Zhi Yi". It comprehensively considers the impact of factors such as constitution, season and environment on the onset and progression of the disease, exploring the application of San Yin Zhi Yi treatment for pediatric CVA from the three aspects of adapting to the season, region and individual. The aim is to provide a better theoretical foundation and practical guidance for the future TCM treatment of pediatric CVA. Related Articles | Metrics

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Analysis of the current status of clinical practice guidelines and diagnosis and treatment norms for children with pneumonia in recent 20 years WANG Bo, XIONG Lei, WANG Ziwei, BIAN Ji, YANG Shaoying, HE Xiying, MING Xi Chinese Pediatrics of Integrated Traditional and Western Medicine    2025, 17 (1): 39-44.   DOI: 10.20274/j.cnki.issn.1674-3865.2025.01.008 Abstract （2738）      PDF（pc） （1291KB）（570）       Knowledge map    Save By searching CNKI, China biomedical literature service system, Wanfang data knowledge service platform, Weipu Chinese science and technology journal full-text database, Pubmed, Embase and other databases, as well as Yimaitong, NICE,NGC,GIN and other websites, clinical practice guidelines and diagnosis and treatment norms for pediatric pneumonia were sorted out, and literature was independently screened by researchers. After extracting the data, the AGREE Ⅱ tool is used to evaluate the quality of the formulation methodology of the guidelines and diagnosis and treatment norms, and the recommended level is obtained, in order to grasp the formulation methods and quality status of clinical practice guidelines for childhood pneumonia at home and abroad, and to provide reference for the future formulation of high-quality clinical practice guidelines in professional fields. Related Articles | Metrics

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Analysis of the development of treatment for pediatric rhinitis from the perspectives of deficiency and cold syndromes and the application of Xu's pediatrics theory of supporting yang CUI Chen, LI Jingwei, ZHOU Junhui, YANG Chuwen, ZHAO Jun, PU Xiaowei Chinese Pediatrics of Integrated Traditional and Western Medicine    2025, 17 (1): 67-70.   DOI: 10.20274/j.cnki.issn.1674-3865.2025.01.014 Abstract （2695）      PDF（pc） （1054KB）（363）       Knowledge map    Save Pediatric rhinitis is a common nasal disorder in children. TCM practitioners throughout history have extensively discussed its etiology and pathogenesis. This article traces the literature and historical origins of treatment for pediatric rhinitis from the perspectives of deficiency and cold syndromes. It is pointed out that external cold is a common cause. The root cause of its recurrence is the deficiency and damage of the lungs, spleen and kidneys. The pathogenesis involves lung-qi deficiency and coldness, leading to insufficient defense of the exterior; kidney-yang deficiency results in a lack of warmth and nourishment; spleen and stomach weakness leads to the failure of ascending clear yang; all of the above factors contribute to the development of pediatric rhinitis. Additionally, the article delves into Xu's pediatrics theory of supporting yang and its application, aiming to provide assistance for clinical practice. Related Articles | Metrics

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Professor Li Xinmin's experience in treating refractory nephrotic syndrome in children with the method of dredging and regulating the triple energizer CHEN Hongxiang, LI Xinmin, HAN Yaowei, QIN Luping Chinese Pediatrics of Integrated Traditional and Western Medicine    2025, 17 (1): 71-74.   DOI: 10.20274/j.cnki.issn.1674-3865.2025.01.015 Abstract （2675）      PDF（pc） （1059KB）（434）       Knowledge map    Save Refractory nephropathy in children is one of the difficulties that need to be urgently addressed in clinical practice. Based on years of clinical experience, Professor Li Xinmin believes that "dysfunction of the pivot of the triple energizer" is the core pathogenesis, and advocates the basic treatment principle of "dredging and regulating the qi movement of the triple energizer, with particular emphasis on the spleen and stomach in the middle energizer". Clinically, he is good at restoring the qi transformation of the triple energizer by coordinating the ascending and descending of the qi movement of the "lung, spleen, stomach and liver" thereby normalizing the water and fluid metabolism function. Meanwhile, he advocates treating the disease based on stages. In the acute recurrence stage, emphasis is placed on clearing and dispersing the lung qi in the upper energizer, and Yinqiao Silian decoction with modification is often used. In the remission stage, attention is paid to dredging and promoting the spleen and stomach in the middle energizer, and Weiling decoction with modification is commonly employed. In the protracted stage, focus is on dredging and regulating the qi movement of Shaoyang, and Chaihu Linggui Zhugan decoction with variation is often administered. Professor Sun Liping emphasizes moderation and balance in the prescription and medication, and he is particularly skilled in using the combination of bitterness with acridity to unfold and regulate the pivot. The clinical therapeutic effect is significant. Related Articles | Metrics

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Research advances in the treatment of neurodevelopmental disorders in children with fecal microbiota transplantation HUA Zhichao, CHEN Yuyan, YANG Yufang, CHEN Xiaoling Chinese Pediatrics of Integrated Traditional and Western Medicine    2025, 17 (1): 22-26.   DOI: 10.20274/j.cnki.issn.1674-3865.2025.01.005 Abstract （2642）      PDF（pc） （1122KB）（683）       Knowledge map    Save Fecal microbiota transplantation (FMT), as a method to treat intestinal and extra-intestinal diseases by regulating intestinal flora dysbiosis, has attracted widespread attention in recent years. Its effect in the treatment of children's neurodevelopmental disorders (NDDs) has gradually been verified, showing great application prospects, which provides new strategies for the treatment of NDDs. This article explores its clinical efficacy, development prospects and some technical limitations that still exist at present by summarizing the relevant animal and clinical studies on FMT treatment for NDDs, aiming to provide relevant references for the subsequent clinical treatment of NDDs. Related Articles | Metrics

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Experience in Xu's tranquilizing method of suppressing yang in the treatment of insomnia in children LIU Xuhua, JIANG Yonghong Chinese Pediatrics of Integrated Traditional and Western Medicine    2025, 17 (1): 63-66.   DOI: 10.20274/j.cnki.issn.1674-3865.2025.01.013 Abstract （2540）      PDF（pc） （1077KB）（385）       Knowledge map    Save In Xu's pediatrics of Shanghai traditional Chinese medicine, it is believed that the pathogenesis of children's insomnia lies in the rise of yang and the weakness of yin, so the treatment is as follows: on the basis of warming the lower and suppressing yang, Huanglian Ejiao decoction is used to warm yang and nourish yin and to control water and fire and yin and yang to restore its normal state, thus forming a treatment with the characteristics of Shanghai traditional Chinese medicine. Based on the warming and suppressing method of Xu's pediatrics of Shanghai traditional Chinese medicine, this paper explores Xu's understanding of etiology and pathogenesis of insomnia in children, and analyzes the characteristics of prescription and medication of tranquilizing method by suppressing yang through the combination with the development characteristics of etiology and pathogenesis in children. A case is included here to provide some references for clinical practice. Related Articles | Metrics

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A multi center clinical study on the adjuvant treatment with Fuxiong powder for children with Mycoplasma pneumoniae pneumonia SHEN Hongyan, ZHANG Xiuying, TAN Chunying, SHANG Tao, MENG Bin, MU Jingwen, TIAN Zhifan, E Mingxin, WANG Xuefeng Chinese Pediatrics of Integrated Traditional and Western Medicine    2025, 17 (2): 93-98.   DOI: 10.20274/j.cnki.issn.1674-3865.2025.02.001 Abstract （2540）      PDF（pc） （1055KB）（465）       Knowledge map    Save Objective:To evaluate the clinical efficacy and safety of Fuxiong powder in the adjuvant treatment of Mycoplasma pneumoniae pneumonia（phlegm-heat closing lung syndrome） in children.Methods:Totally 120 children with Mycoplasma pneumoniae pneumonia（phlegm-heat closing lung syndrome） were selected as the study subjects,who were admitted to the Affiliated Hospital of Liaoning University of Traditional Chinese Medicine，Liaoning Provincial Maternal and Child Health Hospital，Benxi Manchu Autonomous County Hospital of Traditional Chinese Medicine and Kaiyuan Hospital of Traditional Chinese Medicine from October 2024 to January 2025，and they were divided into two groups according to their wishes:60 cases in the experimental group and 60 cases in the control group.The control group was treated with basic treatment with western medicine，and the experimental group was treated with Fuxiong powder in addition to the basic treatment with western medicine.The course of treatment was 7 d.The clinical efficacy，time to remission of main symptoms，disappearance time of pulmonary signs（rales），TCM syndrome scores and adverse reactions were compared between the two groups.Results:After treatment，the healing and improvement rate of experimental group was 72%-22% (39/54),and the total effective rate was 92%-59% (50/54),both of which were higher than the control group ［(50%-91%,28/55）and (83%-64%,46/55)］,showing that the clinical efficacy of the experimental group was better than that of the control group (P<0.05).The relief time of clinical symptoms（cough，wheezing due to retention of phlegm in the throat，shortness of breath） and the disappearance time of pulmonary signs (rales) in the experimental group were both less than those in the control group (P<0.05).The TCM syndrome score was lower than before treatment in both groups，and the experimental group was better than the control group (P<0.05).There was no significant difference in the incidence of adverse events between the two groups（P>0.05）.Conclusion:The adjuvant treatment for Mycoplasma pneumoniae pneumonia（phlegm-heat closing lung syndrome） in children with Fuxiong powder has a good clinical efficacy，which can effectively promote rales absorption and improve the symptoms of cough,wheezing due to retention of phlegm in the throat and shortness of breath，and is safe.  Related Articles | Metrics

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Meta analysis and GRADE evaluation of Xiaoer Feire Kechuan oral liquid in the treatment of Mycoplasma pneumoniae pneumonia WU Pan, HUANG Tingyue, ZHANG Zhanling, WANG Xuefeng Chinese Pediatrics of Integrated Traditional and Western Medicine    2025, 17 (2): 98-108.   DOI: 10.20274/j.cnki.issn.1674-3865.2025.02.002 Abstract （2498）      PDF（pc） （7421KB）（177）       Knowledge map    Save Objective:To systematically evaluate the efficacy and safety of Xiaoer Feire Kechuan oral liquid in the treatment of Mycoplasma pneumoniae pneumonia.Methods:Randomized controlled trials of Xiaoer Feire Kechuan oral liquid in the treatment of Mycoplasma pneumoniae pneumonia published in Chinese databases and English databases,including CNKI,Wanfang,VIP,CBM,Pubmed,Cochrane Library and Embase,were searched for by computer and the relevant grey literature was traced.Two researchers conducted literature screening and data extraction separately,and conducted quality evaluation of the included studies.The meta analysis and evidence quality evaluation were carried out using RevMan 5-4 software and GRADE system respectively.Results:A total of 16 studies were included,involving a total of 1 503 patients,752 patients in the experimental group and 751 patients in the control group.The results of meta analysis showed that the total effective rate,the antipyretic time,the disappearance time of cough,the disappearance time of sputum,the disappearance time of lung rales,CRP level,IL6 level and TNFα level were better by Xiaoer Feire Kechuan oral liquid than by conventional western medicine in the treatment of Mycoplasma pneumoniae pneumonia,and the incidence of adverse reactions was not increased.The grading results of GRADE evidence showed that the evidence of total effective rate,the disappearance time of sputum and the incidence of adverse reactions was the low grade;the evidence of antipyretic time,the disappearance time of cough and the disappearance time of lung rales,inflammatory indexes(CRP,IL6,TNFα） and lung function（FEV1,FEV1/FVC,MVV） was the very low grade.Conclusion:The therapeutic effect of Xiaoer Feire Kechuan oral liquid on Mycoplasma pneumoniae pneumonia in children is definite,and its safety is superior to conventional western medicine treatment. Related Articles | Metrics

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Screening for malnutrition risks and analysis of influencing factors in children with pertussis YAN Xili, LIU Jing, HU Qiaomei, TAO Yuqiong Chinese Pediatrics of Integrated Traditional and Western Medicine    2025, 17 (1): 50-54.   DOI: 10.20274/j.cnki.issn.1674-3865.2025.01.010 Abstract （2491）      PDF（pc） （1077KB）（217）       Knowledge map    Save Objective To analyze the risk factors for malnutrition in children with pertussis.Methods Totally 124 children with pertussis hospitalized for treatment in Hunan Children′s Hospital from March 2023 to March 2024 were selected as the research subjects.The children were grouped according to whether they had malnutrition,and the indicators with statistical significance in the single factor were included in Logistic regression analysis.Results The malnutrition assessment score for 124 children with pertussis was (3.59±1.74),including 38 cases (30.65%) with malnutrition and 86 cases (69.35%) with normal nutrition.The results of Logistic regression analysis showed that age,severity of disease,presence of other diseases,uncertainty about disease,and sleep status were risk factors for malnutrition in the children (P<0.05).Conclusion Severe malnutrition exists in hospitalized children with pertussis,and low age,severe illness,comorbidities,high levels of uncertainty about disease in family members and poor sleep conditions are all independent risk factors for malnutrition in children.Scientific and reasonable feeding should be carried out to reduce the incidence of malnutrition in children. Related Articles | Metrics

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Risk factors for Mycoplasma pneumoniae pneumonia with plastic bronchitis in children:a systematic review and Meta-analysis LUO Zihao, GENG Gang, WANG Yanhong, LI Shaojun Chinese Pediatrics of Integrated Traditional and Western Medicine    2024, 16 (6): 500-508.   DOI: 10.3969/j.issn.1674-3865.2024.06.009 Abstract （2432）      PDF（pc） （3957KB）（539）       Knowledge map    Save Objective:To systematically evaluate the risk factors for Mycoplasma pneumoniae pneumonia with plastic bronchitis in children.Methods:Computer retrieval was conducted in PubMed,Embase,Web of Science,Cochrane Library,CBM,Chinese Medical Journal Full-text Database,Wanfang Database,VIP and CNKI to collect related studies on risk factors for Mycoplasma pneumoniae pneumonia with plastic bronchitis in children.The retrieval period was from the establishment of the databases to February 2024.Meta-analysis was performed using Stata 18.0 and RevMan 5.4 software.Results:A total of 17 studies were included,all being case-control studies,involving 4 336 children.The results of Meta-analysis showed that fever duration［OR=4.45,95%CI(3.32-5.96),P<0.001］,C-reactive protein(CRP)［OR=1.45,95%CI(1.28-1.65),P<0.001］,D-dimer［OR=2.21,95%CI(1.27-3.85),P=0.005］,neutrophil ratio(N%)［OR=1.47,95%CI(1.17-1.85),P=0.001］,pleural effusion［OR=3.63,95%CI(2.77-4.76),P<0.001］,atelectasis［OR=4.03,95%CI(2.46-6.63),P<0.001］ and allergy history［OR=3.04,95%CI(2.39-3.78),P<0.001］ were positively correlated with Mycoplasma pneumoniae pneumonia complicated with plastic bronchitis in children,while lymphocyte ratio(L%)［OR=0.71,95%CI(0.52-0.96,P=0.030)］ was negatively correlated with it,and lactate dehydrogenase(LDH)［OR=1.02,95%CI(1.00-1.03),P=0.020］ was not an influencing factor for it.Conclusion:Current evidence shows that the longer the fever duration,the higher the proportion of CRP,D-dimer and neutrophils,and the lower the proportion of lymphocytes;combination with atelectasis,pleural effusion,and allergic history are risk factors for Mycoplasma pneumoniae pneumonia with plastic bronchitis in children. Related Articles | Metrics

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Advances in diagnosis and treatment of pediatric mesenteric lymphadenitis based on integrated traditional Chinese and western medicine Minli GUAN, Xiaolin GAO Chinese Pediatrics of Integrated Traditional and Western Medicine    2026, 18 (2): 128-132.   DOI: 10.20274/j.cnki.issn.1674-3865.2026.02.007 Abstract （2431）   HTML （14）    PDF（pc） （595KB）（168）       Knowledge map    Save Mesenteric lymphadenitis in children is a common pediatric abdominal pain disorder, which has the characteristics of repeated attacks and prolonged course of disease, seriously affecting the physical and mental health and quality of life of children. At present, there is no unified consensus on the diagnostic criteria and treatment of the disease. Anti-infection and symptomatic treatment are still the main clinical treatments, but long-term use of antibiotics can easily cause intestinal flora imbalance and drug resistance. In recent years, the role of probiotics in regulating intestinal microecology, reducing inflammation, shrinking lymph nodes, and assisting the treatment of children with mesenteric lymphadenitis has received increasing attention. The core treatment in traditional Chinese medicine (TCM) is regulating qi and relieving pain, reducing swelling and resolving nodules, and invigorating spleen and stomach, and various interventions are performed, such as oral administration of Chinese medicines, acupoint application, moxibustion and massage, which has achieved great effect. Integrated traditional Chinese and western medicine can synergistically enhance the effect, reduce the recurrence rate and improve the compliance, showing a good application prospect. This article systematically reviews the research progress in etiology, pathogenesis, key diagnostic points, western medicine treatment, traditional Chinese medicine treatment, integrated traditional Chinese and western medicine and probiotics application in children with mesenteric lymphadenitis, and sorts the limitations and controversies of current diagnosis and treatment, so as to provide references for standardized clinical diagnosis and treatment and subsequent researches. Reference | Related Articles | Metrics