Abstract:

Objective：To observe the influence of Yiqi Guben capsule on the spleen lymphocyte proliferation function and organ index in the kidney-Yang deficiency asthma model mice and to explore its clinical significance.Methods:Totally 96 mice were randomly divided into seven groups: normal control group, asthma group, the kidney-Yang deficiency asthma group, kidney-qi-tonifying pill group, the Yiqi Guben capsule low-dose group, middle-dose group, high-dose group. Apart from the asthma group consisting of 12 mice, the remaining groups each consisted of 14 mice(male and female in half). kidney-Yang deficiency asthma groups were treated with Yiqi Guben capsule. Recorded changes in the general condition of the mice in each group during modeling and the period of administration, such as, body weight, body temperature and activity, hair color, diet, breathing frequency, etc. After the experiment, took the spleen and examined the lymphocyte proliferation function; took the kidney, spleen and thymus, and weighed them and calculated the organ coefficient.Resluts:In the Yiq Guben capsule group and kidney-qi-tonifying pill group, the mice weight and thymus weight were significantly higher than the kidney-Yang deficiency asthma group; in the Yiqi Guben capsule middle-dose group, the high-dose group and kidney-qi-tonifying pill group, the spleen lymphocyte proliferation by LPS stimulation was significantly higher than the kidney-Yang deficiency asthma group.Conclusion:Yiqi Guben capsule can significantly improve the general state of the kidney-Yang deficiency asthma mice, restore immune organ weights, and improve the function of the spleen lymphocyte proliferation.