Abstract:
Objective：To observe the impact of Yiqi Guben capsule on the splenic lymphocyte in vitro proliferation and organ exponent of spleen-Qi deficiency asthma mice and study its significance.Method：Totally 96 mice were randomly divided into 7 groups, apart from the asthma group consisting of 12 mice, the remaining groups each consisted of 14 mice(male and female in half). They were normal control group, asthma group, spleen-Qi deficiency asthma group, Shibeigao-erbao granule group, the Yiqi Guben capsule low-dose group, middle-dose group and high-dose group. Lymphocyte transformation test was used to measure the function of splenic lymphocyte in vitro proliferation; the spleen, thymus, and kidney were taken and weighed, the organ exponent was calculated and the differences were compared between each group.Result：The mice's thymus weight in the Yiqi Guben capsule low-dose group，middle-dose group, high-dose group and Shibeigao-erbao granule group did not increase significantly; the spleen lymphocyte proliferation stimulated by lipopolysaccharide in Yiqi Guben capsule middle-dose group, high-dose group and Shibergao-erbao granule group was significantly higher than the spleen-Qi deficiency asthma group(P<0.05).Conclusion：Yiqi Guben capsule can significantly improve the asthma state of spleen-Qi deficiency asthmatic mice, and improve the function of spleen lymphocyte proliferation.