Abstract: Objective To analyze the medication rules of national patent Chinese herbal compound prescriptions for eczema and atopic dermatitis based on data mining in order to direct the development of new medicines and basic researches.Methods We searched for Chinese herbal compound patents for the treatment of eczema and atopic dermatitis in the State Intellectual Property Office's patent database, and we statistically analyzed those patents using the bibliometric approach, data mining analysis, association rule analysis, etc.. Using the TCM Heritage Assist Platform V2.5, we created association rule network diagrams using SPSS Modeler 18.0 and made cluster analysis using SPSS 26.0.Results This study examined 380 herbal medicines used in a total of 425 internal Chinese herbal compound formulas for the treatment of eczema and atopic dermatitis. All of the medicines were bitter and cold in nature, with Kushen, Difuzi, Huangbai and Baixianpi serving as the main ingredients; the majority of them functioned through the liver, stomach, lung, and spleen meridians. Further investigation into potential new prescriptions was made.Conclusion The fundamental principle of "clearing heat and dampness, dispelling wind and relieving itch" is summarized as the main principle of clinical application of TCM for eczema and atopic dermatitis, and data mining provides new theoretical foundation for clinical prevention and therapy.

Key words:

Eczema, Atopic dermatitis, Data mining, TCM heritage assist platform