加味清心莲子饮治疗肾病综合征激素撤减期临床研究

doi:10.3969/j.issn.1674-3865.2021.01.022

Abstract

Abstract: Objective:To observe the effect of Jiawei Qingxin Lianzi decoction on nephrotic syndrome during hormone withdrawal.Methods:From March 2018 to March 2019, 70 children with simple nephrotic syndrome were treated the Second Outpatient Department of the First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, and they were randomly divided into two groups. On the basis of conventional hormone therapy, 35 cases in the control group were treated with Huaiqihuang granules, and 35 cases in the experimental group were given Jiawei Qingxin Lianzi decoction, the course of treatment being 8 weeks. The TCM symptom scores, side effects and height growth were compared between the two groups before and after treatment, and the relapse after treatment was also compared.Results:There were 3 cases who were lost of follow-up in experimental group and 5 cases in the control group. After treatment, the TCM symptom score, recurrence rate and incidence of side effects in the experimental group were lower than those in the control group, and the difference was statistically significant(P<0.05); the total effective rate in experimental group was 90.6%(29/32), which was higher than that in control group(60.0%, 18/30)(P<0.05); the increase in height of the children in the experimental group was higher than that in the control group, and the difference was statistically significant(P<0.05).Conclusion:Jiawei Qingxin Lianzi decoction has a synergistic and detoxifying effect on hormone treatment for nephrotic syndrome, and reduces the recurrence rate and improves the prognosis of children.

Key words: Nephrotic syndrome, Glucocorticoid, Deficiency of both Qi and Yin, Jiawei Qingxin Lianzi decoction, Detoxification and synergism

WANG Hai, WU Mingyue, ZHANG Yongzheng. Clinical study of Jiawei Qingxin Lianzi decoction in the treatment of nephrotic syndrome during hormone withdrawal period[J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2021, 13(1): 76-.

[1]	Meifang CHEN, Jian ZHENG. Professor Zheng Jian's experience in treating refractory nephrotic syndrome in children based on the principle of "phased collaboration and sequential synergy" [J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2026, 18(2): 141-146.
[2]	Ruiying PAN. Analysis of clinical related factors of glucocorticoid-induced ocular hypertension in children with primary nephrotic syndrome [J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2025, 17(5): 424-428.
[3]	CHEN Hongxiang, LI Xinmin, HAN Yaowei, QIN Luping. Professor Li Xinmin's experience in treating refractory nephrotic syndrome in children with the method of dredging and regulating the triple energizer [J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2025, 17(1): 71-74.
[4]	SHEN Xiaoyu, WANG Cuijin, WU Yan, YIN Lei, SUN Kexing, SHA Sha, WANG Xuefeng. Professor Wang Xuefeng's experience in treating refractory nephritic syndrome combined with atopic dermatitis in children [J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2024, 16(1): 72-76.
[5]	PAN Ruiying. Study on glucocorticoid-induced eye damage in children with primary nephrotic syndrome [J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2023, 15(3): 203-207.
[6]	LI Le, LI Bing, YANG Meng, GAO Xuguang, ZHAO Yongwang, ZHAI Wensheng. Study on the the relationship between "heat", "blood stasis" as well as "deficiency" and refractory nephropathy in children based on the theory of "Fu Xie" in traditional Chinese medicine [J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2023, 15(1): 67-70.
[7]	YANG Lan, ZHUANG Xiangli, YAN Shuiping, ZHENG Jian. Professor Zheng Jian's treatment for primary nephrotic syndrome in children based on "kidney governing deficiency [J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2022, 14(4): 361-364.
[8]	ZHAO Like, ZHANG Maoxia, MA Hong. Research progress in genes and gene polymorphisms related to steroid-resistant nephrotic syndrome [J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2022, 14(2): 123-126.
[9]	WANG Xiaoran, ZHENG Pan, SUN Shijie. Analysis of global registration of clinical trials in children with idiopathic nephrotic syndrome [J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2021, 13(6): 480-484.
[10]	GAO Xuguang, YANG Meng, ZHANG Maohua, ZHAI Wensheng. Evaluation of therapeutic effect of Yiqi Huayu Qingre decoction on pediatric hormone-sensitive nephrotic syndrome [J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2021, 13(4): 358-362.
[11]	HU Mingge, LI Xuejun, DU Mengke, ZHANG Xia, DING Ying. Professor Ding Ying's experience in treating pediatric refractory nephrotic syndrome [J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2020, 12(2): 141-144.
[12]	KONG Yali, LIAN Pengqiang, AN Ni, ZHENG Ping, ZENG Zhiyong. . Evaluation of pulmonary function in infants with wheezing and the effectiveness of drug intervention [J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2019, 11(6): 528-533.
[13]	MA Mingxing, WANG Xuefeng, SHAN Hongmei, ZHANG Xiuying, LI Linfeng, WANG Yawen. Meta-analysis of the efficacy of traditional Chinese medicine combined with cyclophosphamide in the treatment of refractory nephrotic syndrome in children [J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2019, 11(5): 408-414.
[14]	WEI Lei, LIU Cuihua. Clinical study on Wenyang Bushen method in the treatment of primary refractory nephrotic syndrome in children [J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2019, 11(1): 54-58.
[15]	LIANG Dianzhe, SHANG Huiqin. Clinical observation on treatment for nephrotic syndrome in children with Guben Quyu Huashi decoction [J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2019, 11(1): 19-22.

Clinical study of Jiawei Qingxin Lianzi decoction in the treatment of nephrotic syndrome during hormone withdrawal period

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments