Abstract: Objective:To explore the clinical features of hospitalized children with multiple resistant bacteria and summarize effective treatment strategies in order to provide reference for reasonable use of antibiotics.Methods:In the children hospitalized for treatment in Tongren People's Hospital from Jan. 2014 to Dec. 2016,there were 88 children with multidrug resistant bacteria infection. The clinical features of these children were comprehensively analyzed(including systematic inflammatory response, routine blood test, C-reactive protein and calcitonin). The treatment strategies and prognosis were also analyzed to decide whether the drugs used according to experience were adjusted to sensitive antibiotics. The children were divided into two groups: the adjusted antibiotic group(group A,17 cases) and the non adjusted antibiotic group(group B,71 cases).Results:The white blood cell count, neutrophil proportion, and calcitonin increased in group A, while C-reactive protein decreased, but there was no statistical difference in WBC count between group A and group B(P>0.05);there was statistical difference in neutrophil proportion, C-reactive protein and calcitonin between the two groups(P<0.05). The systematic inflammatory response was obvious in group A, but not obvious in group B. The cure rate of group B was 95.8%(68/71), which was higher than that of group A(76.5%,13/17). The mean length of hospital stay was (7.44±1.13)d in group B, shorter than that of group A［(10.22±2.53)d,P<0.05］.Conclusion:In clinical work, it is necessary to scientifically analyze the clinical features and monitoring results, make correspondent treatment strategies use antibiotics reasonably in order to guarantee the effect and safety of the treatment.

Key words: Multiple resistant bacteria, Clinical features, Treatment strategy, Prognosis, Child