Abstract: Objective: To observe the effect of triple therapy for children with functional dyspepsia complicated by positive Helicobacter pylori(Hp) infection.Methods: From Mar. 2014 to Mar. 2016, a total of 116 children with functional dyspepsia complicated by Hp infection were hospitalized for treatment in Xili Children's Hospital of Nanshan District in Shenzhen City, who were randomly divided into two groups: observation group(58 cases) and control group(58 cases). The control group was given domperidone orally taken, and for the observation group, triple therapy(omeprazole+clarithromycin+amoxicillin) was performed in addition to the treatment for the control group, 10 days as a treatment course. Observe the clinical effect, Hp eradication after treatment and the adverse reactions in the two groups.Results: The total effective rate of observation group was 91.4%(53/58), higher than that of the control group 74.1%(43/58), the difference being statistical(P<0.05). The Hp eradication rate in observation group was 94.8%(55/58), significantly higher than that in the control group(51.7%,30/58) and there was statistical difference(P<0.01). There was no statistical difference on the rate of adverse reactions between the two groups during treatment(P>0.05).Conclusion: Triple therapy is quite effective and safe in the treatment of children with functional dyspepsia complicated by positive Hp infection, and should be clinically used.

Key words: Functional dyspepsia, Triple therapy, Helicobacter pylori, Children