Abstract: Objective：To observe the effect of Xiaoban Yushen compound on renal tissue IL-13 expression and circulating immune complexes(CIC) serum concentration and to study the mechanism of its treatment for IgA nephropathy.Methods：The rats were randomized into normal group，model group，telmisartan group and Xiaoban Yushen compound group, with 10 rats in each group．Bovine serum albumin(BSA) was taken orally to make experimental IgA nephropathy rat model. Xiaoban Yushen compound and telmisartan were given at the eighth week of the experiment for gavage, once daily for five consecutive weeks; at the end of the 12th week, blood was taken to detect immune complexes content, and kidney tissue was taken to detect IL-13 expression.Results：Compared with the model group, IL-13 expression and serum concentration of CIC in Xiaoban Yushen compound group decreased (P<0.01); compared with telmisartan group, IL-13 expression and serum CIC concentration in Xiaoban Yushen compound group decreased (P<0.05); both differences had statistic significance.Conclusions：Xiaoban Yushen compound plays a role in regulating IL-13 expression in renal tissue and serum CIC concentration of IgA nephropathy.