Abstract:
Objective：To discuss the Yiqi Guben capsule role in regulating the splenic lymphocyte proliferation of lung-Qi deficiency mice.Methods：Totally 96 mice (male and female in half) were equally divided into 6 groups: normal control group, model group, Yiqi Guben capsules high-dose group, middle-dose group and low-dose group, control group of Yupingfeng powder. Apart from the normal group, the mice in the rest of each group were made into lung-Qi deficiency syndrome models by adopting improved smoked method; tested drugs were given by intragastric administration for five weeks; XTT method was taken to assay the proliferation of splenic lymphocyte stimulated by the LSP or ConA.Results：After lung-Qi deficiency modeling，the function of the splenic B and T lymphocyte proliferation was significantly lower than the normal control group (P<0.001)；after the tested drugs were given by intragastric administration, the function of splenic B and T lymphocyte proliferation was significantly increased; compared  with the model group, the splenic lymphocyte proliferation function of control group, of Yupingfeng powder group, of Yiqi Guben capsule high-dose group and middle-dose group was significantly increased(P<0.05)，and the increase of Yiqi Guben capsule high-dose group was the most significant.Conclusions：Yiqi Guben capsule can improve the lymphocyte proliferation activity of lung-Qi deficiency mice，thereby regulate the immune function.