Abstract: Objective：To study the effect of evidence-based nursing on the development and rehabilitation of neonates with hypoxic ischemic encephalopathy.Methods：A total of 220 children were included as the research subjects,who were treated in Hunan Children's Hospital from Jan. 2014 to Jan. 2016,and they were randomly divided into basic group(110 children) and evidence-based group(110 children).Basic nursing was carried out in the basic group,while for the evidence-based group,the evidence-based problem was made clear first and the evidence-based nursing scheme was designed,and then the evidence-based nursing was carried out,including disease condition monitoring,education about the disease and rehabilitation training. 〖ＪＰ２〗Evidence-based evaluation was performed after the nursing. Observe the treatment results and the incidence of pneumonia in the two groups;one-year follow-up was carried out for the two groups of children,and compare the intelligence development,motor development,and Gesell score of cerebral palsy rehabilitation.Results：The total effective rate of evidence-based group was 90.9%(100/110),significantly higher than that of basic group(76.4%,84/110),and there was statistical difference(P<0.05).The incidence rate of pneumonia was 4.5%(5/110)in the evidence-based group,which was significantly lower than that in basic group(25.5%,28/110),the difference being statistical(P<0.05).After one year,the intelligence development,motor development and Gesell score were significantly higher in evidence-based group than in basic group,and the difference is of statistical significance(P<0.05).Conclusion：The evidence-based nursing can effectively improve the development and rehabilitation of the neonates with hypoxic ischemic encephalopathy.

Key words: Hypoxic ischemic encephalopathy, Evidence-based nursing, Development, Rehabilitation, Infant,newborn