ISSN 1674-3865  CN 21-1569/R
主管:国家卫生健康委员会
主办:中国医师协会
   辽宁省基础医学研究所
   辽宁中医药大学附属医院

Chinese Pediatrics of Integrated Traditional and Western Medicine ›› 2014, Vol. 6 ›› Issue (2): 122-125.doi: 10.3969/j.issn.1674-3865.2014.02.010

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The effect of carnosine pretreatment on cognition function of HI rat

ZHANG Xiang min,ZHANG Zhan,CHENG Xiu yong,et al.   

  1. Department of Pediatrics,the Third Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China
  • Received:2013-11-08 Published:2014-04-25 Online:2014-04-25

Abstract: Objective:To explore the effects of carnosine pretreatment on cognitive function in hypoxic ischemia (HI) rats.Methods:A total of 36 SD rats,7 days after birth,were ligated and cut off the left common carotid artery;they inhaled 8% oxygen and nitrogen mixture for 2 h to induce HI,and then these SD rats were randomly divided into 3 groups (n=12):(1) carnosine pretreatment group:given intraperitoneal injection of carnosine 250 mg/kg at a time 30 min before the HI induction;(2) the HI groups:under the same condition , the same volume of physiological saline was used instead;(3) control group:no treatment or management was given.Some 21~26 days after HI,  by Morris water maze experiment——navigation trial and space probe trial,the effect of carnosine on swimming time,distance,and percentage of time spent in the target quadrant was evaluated.Results:Carnosine pretreatment reduced swimming time,shortened swimming distance,and increased percentage of time spent in the target quadrant of HI rats.Conclusion:Carnosine pretreatment improves the cognitive function of the HI rats,hence effectively plays its role in the nerve protection.

Key words: hypoxic-ischaemic cerebropathy, asphyxia, carnosine, diagnosis application, cognitive function, rat, animal, test