Abstract: Objective：To investigate the relationship between oxytocin receptor（OXTR）gene polymorphism and childhood autism in Han population in Jiamusi.Methods：Polymerase chain reaction-restricted fragment length polymorphism(PCR-RFLP) was used to determine allele and genotype of SNP(rs2254298) of OXTR in 30 Chinese Han autism children staying in the 3rd Affiliated Hospital of Jiamusi University and 30 normal children in a kindergarten and an elementary school in Jiamusi from May to December,2007.Results：The genotype distribution of the SNP(rs2254298) in patient group and control group was consistent with the Hardy-Weinberg equilibrium(P>0.05).There was significant difference in the distribution of the allelic frequencie and genotype in rs2254298 between the two groups(P＜0.05).Conclusions：There is an association between the SNP(rs2254298) of OXTR and childhood autism.

Key words: Autism;Developmental disorders;Receptor, oxytocin;Child