Abstract: Objective：To study the effect of early behavior therapy to reduce cerebral palsy caused by brain damage in rats.Methods：Totally 27 pregnant rats were consecutively injected with LPS(450 μg/kg，n=21) or saline(n=6) on gestation 18 d and 19 d.We selected randomly saline neonatal rat group B(n=30) and LPS neonatal rat group A1(n=20)，A2(n=30).The 2 d rats(A1) were given early behavior therapy，such as enriched environment and the rats(A2 and B) were routinely fed.The neurobehavior of the rats was observed in A1，A2 and B groups on 25 d.The MBP and S100 were detected in brain sections on 1 d and 25 d.Results：MBP expression was obviously decreased in A2(1 d),compared with B of 1 d rats(P<0.01);MBP was increased in A1 of 25 d,compared with A2 of 25 d(P<0.05)；it was increased in B,contrasted with A1 and A2(P<0.01).Compared with B,there was significant increase in A2 of 1 d with regard to S100(P<0.01).The result of S100 between A2 and B of 25 d was the same with 1 d rats,but the S100 of A1 was the middle of them（P<0.01）．The result of neurobehavioral observation indicated that there were 4 cerebral palsy rats in A1,8 cerebral palsy rats in A2 and no cerebral palsy rat in B.Conclusion：MBP and S100 can become the sign of early diagnosis and the therapeutic effect in brain injury.Early interference can reduce cerebral palsy.

Key words: Cerebral palsy;Brain damage;Behavior therapy;Rat；Animal, experiment