Abstract: Tic disorder(TD) is a neuropsychiatric disorder,the exact causes and mechanisms of which are not yet fully understood.In recent years,the prevalence of tic disorder has been on the rise.Patients with TD often present with comorbidities such as attention deficit hyperactivity disorder,obsessive compulsive disorder,learning difficulties,anxiety,and depression.These issues not only negatively impact children's academic performance but may also bring great trouble to their growth,development,and mental health.Researches have indicated that the occurrence of TD is closely related to various factors,including neurotransmitter imbalance,genetic factors,psychosocial factors,and infections or immune factors.Neurotransmitters play a crucial role in maintaining normal function of nervous system,and in TD patients,there may be neurotransmitter imbalance,which affects their behavior and cognitive functions.In depth research in the pathogenesis of TD,especially in neurotransmitter imbalance,helps us better understand its pathological processes and provides new therapeutic approaches and strategies for controlling its symptoms.Through targeted treatment and interventions,symptoms can be effectively alleviated,which helps patients improve their quality of life and reduce the negative impact on society and families.This article mainly reviews the relationship between neurotransmitter imbalance and the development of tic disorder.

Key words: Tic disorders, Pathogenesis, Neurotransmitter imbalance, Child