咳喘平颗粒辅助治疗儿童支气管哮喘发作期的临床观察及对白三烯水平的影响

doi:10.3969/j.issn.1674-3865.2019.06.008

Abstract

Abstract:

Objective:To observe the clinical efficacy of Kechuanping granules in children with cold asthma in the attack of bronchial asthma, and its effect on serum LTB4 and urine LTE4 levels. Methods:Sixty children with cold asthma in the attack of bronchial asthma, who were admitted to the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine from December 1, 2017 to December 31, 2018, were selected as research subjects. They were randomly divided into 31 cases in observation group and 29 cases in control group. The control group was treated with western medicine routinely, and the observation group was treated with Kechuanping granules orally on the basis of the treatment for control group. After 7 days, the changes in the clinical efficacy and TCM syndrome total score of the two groups were observed; the serum LTB4 and urine LTE4 levels were measured by enzyme-linked immunosorbent assay before and after treatment.Results:The total clinical effective rate of the observation group was significantly higher than that of the control group, and the difference was statistically significant (P<0.05). After treatment, the total score of TCM syndromes in both groups was significantly lower than that before treatment, and the difference was statistically significant (P<0.05); the total score of TCM syndromes in the observation group was significantly lower than that in the control group after treatment, and the difference was statistically significant (P<0.05). After treatment, the levels of serum LTB4 and urine LTE4 in the two groups were significantly lower than those before treatment, and the difference was statistically significant (P<0.05). After treatment, serum LTB4 and urine LTE4 levels in the observation group were significantly lower than those in the control group, and the difference was statistically significant (P<0.05).Conclusion:Kechuanping granules can significantly improve the TCM syndrome scores of children with cold asthma during bronchial asthma attack and improve clinical efficacy. Kechuanping granules can reduce serum LTB4 and urinary LTE4 levels in children with bronchial asthma, and its mechanism may be related to the reduction of LTs levels in children.

Key words:

Bronchial asthma, TCM syndrome total score, Kechuanping granules, Leukotriene, Child

CUI Heqing, SHANG Lili..

Clinical effects of Kechuanping granules in adjuvant therapy for bronchial asthma attack in children and its effect on the level of leukotriene [J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2019, 11(6): 483-487.

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Clinical effects of Kechuanping granules in adjuvant therapy for bronchial asthma attack in children and its effect on the level of leukotriene

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