Abstract:
Objective:To compare respiratory support treatment parameters and complications of nasal intermittent pressure ventilation(NIPPV) with nasal continuous positive airway pressure(NCPAP) in very-low-birth-weight(VLBW) preterm infants.Methods:Totally 80 cases of VLBW premature infants were treated in the Second People's Hospital of Shantou from January 2015 to June 2016. They were included as the subjects and were randomly divided into two groups: NIPPV group and group B, each group having 40 cases. Non-invasive respiratory support time, total time with oxygen, 72h domestic replacement use of tracheal intubation and invasive ventilation, pulmonary surfactant use and complications were observed and recorded in detail.Results:The rate of 72h domestic replacement use of tracheal intubation and invasive ventilation and the rate of pulmonary surfactant use in NCPAP group were 40% (16/40) and 62.5% (25/40, 17.5%), which were higher than that of NIPPV group［(17.5%,7/40) and (32.5%,13/40)］, the difference being statistically significant (P<0.05). There was no significant difference between the two groups in the time of non-invasive respiratory support and the total oxygen use time with the auxiliary ventilator(P>0.05). There was no significant difference in the incidence of complications between the two groups(P>0.05).Conclusion:Compared with NCPAP, NIPPV has no significant difference in non-invasive respiratory support time, total oxygen use time and complications, but it can reduce the use of tracheal intubation and use of pulmonary surfactant.

Key words: Neonatal respiratory distress syndrome, Very-low-birth-weight infant, Nasal intermittent positive pressure ventilation, Nasal continuous positive airway pressure, Preterm infant